In the SCI FI Channel original miniseries The Lost Room, Julianna Margulies stars as Jennifer Bloom, a mysterious woman who contacts Det. Joe Miller and claims that her brother was killed for a seemingly innocuous motel room key, one that in fact has the power to unlock a door into a room full of ostensibly ordinary objects that possess unimaginable powers.

When Det. Miller comes into possession of the Key, Jennifer tries to warn him of the inherent danger of the Motel Room and the Objects within. After Miller's daughter Anna vanishes into the room, however, he must form an uneasy alliance with Jennifer, who opens his eyes to a world of secret cabals that will stop at nothing to acquire the Key.

Emmy and Screen Actors Guild award-winner and Golden Globe nominee Julianna Margulies gained recognition for her portrayal of nurse Carole Hathaway in the critically acclaimed series ER. Margulies received her sixth straight Emmy nomination for the 2000 season and twice won the Screen Actors Guild Award for Best Actress in a Dramatic Series for the program.

Most recently she starred in David R. Ellis' Snakes on a Plane, opposite Samuel L. Jackson, and will soon follow with Beautiful Ohio, directed by Chad Lowe and starring Rita Wilson and William Hurt.

She just completed a multi-episode guest role in HBO's The Sopranos opposite James Gandolfini. She recently made her Broadway debut in Festen opposite Michael Hayden, Larry Bryggman, Ali MacGraw and Jeremy Sisto.

Margulies's other film credits include the dark comedy The Darwin Awards, with Winona Ryder and Joseph Fiennes; Slingshot, opposite David Arquette and Balthazar Getty; Ghost Ship, opposite Gabriel Byrne; Bruce Beresford's Evelyn, opposite Pierce Brosnan; What's Cooking, an ensemble drama directed by Gurinder Chadha; Richard Linklater's The Newton Boys; Boaz Yakin's A Price Above Rubies; Jack Green's Traveller; The Man from Elysian Fields, opposite Andy Garcia and Mick Jagger; and Bruce Beresford's Paradise Road.

Her television credits include The Grid, for which she received a Golden Globe nomination; the CBS original movie Jenifer; and TNT's original The Mists of Avalon, with Anjelica Huston and Joan Allen.